Zhanjun Hou Selected Research

Folic Acid (Vitamin M)

1/2022	The evolving biology of the proton-coupled folate transporter: New insights into regulation, structure, and mechanism.
12/2021	Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer.
1/2021	Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
1/2021	Folate transporter dynamics and therapy with classic and tumor-targeted antifolates.
1/2020	Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
1/2020	Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.
12/2019	Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
10/2018	Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
1/2018	Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.
1/2017	Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates.

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Zhanjun Hou Research Topics

Disease

40	Neoplasms (Cancer) 01/2022 - 03/2007
3	Ovarian Epithelial Carcinoma 01/2022 - 01/2017
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018 - 12/2012
2	Malignant Mesothelioma 01/2018 - 04/2013
2	Hereditary Folate Malabsorption 04/2014 - 02/2012
1	Acquired Immunodeficiency Syndrome (AIDS) 05/2022
1	Ovarian Neoplasms (Ovarian Cancer) 01/2022
1	Adenocarcinoma 01/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020
1	Mesothelioma 12/2012
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2008
1	Nervous System Diseases (Neurological Disorders) 01/2008

Drug/Important Bio-Agent (IBA)

27	Folic Acid AntagonistsIBA 01/2022 - 03/2007
21	Folic Acid (Vitamin M)FDA LinkGeneric 01/2022 - 01/2008
19	Proton-Coupled Folate TransporterIBA 01/2021 - 10/2010
17	pyrimidineIBA 01/2022 - 10/2010
12	purineIBA 01/2022 - 10/2010
9	NucleotidesIBA 01/2022 - 12/2012
9	Reduced Folate Carrier ProteinIBA 01/2021 - 03/2007
8	Pemetrexed (MTA)FDA Link 01/2021 - 03/2007
7	glycinamide ribonucleotideIBA 01/2021 - 10/2011
7	Hydroxymethyl and Formyl TransferasesIBA 01/2021 - 10/2011
6	Methotrexate (Mexate)FDA LinkGeneric 01/2021 - 03/2007
5	CarbonIBA 12/2021 - 01/2020
5	Pharmaceutical PreparationsIBA 01/2020 - 03/2007
5	Protons (Proton)IBA 10/2016 - 10/2010
4	Proteins (Proteins, Gene)FDA Link 05/2022 - 03/2007
4	EnzymesIBA 01/2021 - 03/2007
4	SymportersIBA 10/2016 - 10/2010
4	Glutamic Acid (Glutamate)FDA Link 02/2012 - 08/2008
3	Biological ProductsIBA 05/2022 - 10/2010
3	Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)IBA 11/2020 - 10/2019
2	RibonucleotidesIBA 01/2021 - 01/2020
2	ThiophenesIBA 01/2021 - 02/2010
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 11/2020 - 10/2019
2	Adenosine Triphosphate (ATP)IBA 11/2020 - 10/2019
2	PyrimidinesIBA 12/2019 - 05/2009
2	Folic Acid TransportersIBA 04/2014 - 03/2007
2	EstersIBA 10/2011 - 02/2010
2	Polyglutamic Acid (Polyglutamate)IBA 01/2008 - 03/2007
1	ProteomeIBA 05/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	furanIBA 01/2021
1	N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)IBA 01/2021
1	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 11/2020
1	S 6 (S-6)IBA 01/2020
1	Aligeron (AS 2)IBA 01/2020
1	SulfurIBA 01/2020
1	AmidesIBA 12/2019
1	NAD (NADH)IBA 10/2019
1	FluorineIBA 10/2018
1	Cisplatin (Platino)FDA LinkGeneric 01/2017
1	10-propargyl-10-deazaaminopterin FDA Link 04/2014
1	AcidsIBA 02/2010
1	Growth InhibitorsIBA 05/2009

Therapy/Procedure

5	Therapeutics 01/2022 - 03/2007
5	Drug Therapy (Chemotherapy) 11/2020 - 10/2010